Variant antigen gene expression in malaria

Plasmodium falciparum Variant Surface Antigen Expression Patterns during Malaria

The variant surface antigens expressed on Plasmodium falciparum-infected erythrocytes are potentially important targets of immunity to malaria and are encoded, at least in part, by a family of var genes, about 60 of which are present within every parasite genome. Here we use semi-conserved regions within short var gene sequence "tags" to make direct comparisons of var gene expression in 12 clin...

P-121: Cloning and Expression of The Inosine Triphosphate Pyrophosphatase Gene Variant II in E.coli

Background Environmental and cellular inappropriate conditions can cause damages to cells nucleotide poll. Deamination and oxidation damages interfere with cell�s vital reactions. Inosine triphosphate pyrophosphatase (ITPA), an evolutionary conserved enzyme, plays a critical role in elimination of non-canonical bases. In human genome, the ITPA gene is located on chromosome 20 short arm and tran...

Structure and expression of a Trypanosoma brucei gambiense variant specific antigen gene.

The expression-linked copy of the T. b. gambiense variant specific antigen gene LiTat 1.6 is transposed in a 20 kb DNA region devoid of restriction sites, located near a chromosome end. This expression site is very similar to that of T. b. brucei variants 117, 118 (1) and AnTat 1.8. In the basic copy, the transposable element (TE) is flanked by repetitive sequences; it includes the gene copy as...

Splice Variant Search with Gene Expression Data

Alternative splicing is the phenomena that the pre-mRNA transcript from DNA is processed into different mRNAs by spliced different types of introns. The organism can acquire proteins as many times as genes. Therefore to find such splicing variants is risen in the post genome era. We investigate a new method to detect splicing variants with the gene expression data by the oligonucleotide array t...

Modified by Acquired Immunity Causing Severe and Nonsevere Malaria and Is Antigen Expression Varies Between Isolates Variant Surface Plasmodium falciparum